微生物學(xué)博士，講師、碩士生導(dǎo)師。長(zhǎng)沙理工大學(xué)食品與生物工程學(xué)院教師。

E-mail：tangjianli@csust.edu.cn

【個(gè)人簡(jiǎn)介】

2014年長(zhǎng)沙理工大學(xué)獲工學(xué)學(xué)士學(xué)位，2021年湖南師范大學(xué)獲理學(xué)博士學(xué)位。2022年4月至今，長(zhǎng)沙理工大學(xué)食品與生物工程學(xué)院講師、碩士生導(dǎo)師，“功能微生物創(chuàng)制及精準(zhǔn)發(fā)酵研究團(tuán)隊(duì)”核心成員之一。研究方向?yàn)槭称肺⑸锎x工程與合成生物學(xué)，主要從事食品功能微生物的挖掘、機(jī)制解析、代謝調(diào)控、定向改造等食品微生物技術(shù)研究。在Journal of Agricultural and Food Chemistry、Microbial Cell Factories、ACS synthetic biology等SCI期刊發(fā)表論文16篇。主持湖南省自然科學(xué)基金青年項(xiàng)目1項(xiàng)，湖南省教育廳優(yōu)秀青年項(xiàng)目1項(xiàng)，長(zhǎng)沙市自然科學(xué)基金青年項(xiàng)目1項(xiàng)，參與完成科技部“973計(jì)劃”專(zhuān)項(xiàng)項(xiàng)目及國(guó)家自然科學(xué)基金面上項(xiàng)目各1項(xiàng)。

【主講課程】

本科生：《微生物學(xué)》、《微生物學(xué)實(shí)驗(yàn)》、《生物工程綜合實(shí)驗(yàn)》

碩士生：《高級(jí)微生物學(xué)》、《現(xiàn)代食品微生物學(xué)》、《基因工程》

博士生：《酶工程研究進(jìn)展》

【主要研究領(lǐng)域】

1.傳統(tǒng)發(fā)酵食品功能微生物資源挖掘

2.微生物代謝工程及其調(diào)控

3.微生物基因編輯及合成生物學(xué)

【主要科研項(xiàng)目】

1.湖南省自然科學(xué)青年基金項(xiàng)目：食竇魏斯氏菌降解釀造醬油中有害生物胺的機(jī)制研究（2024JJ6022），5萬(wàn)元，2024-2026年，主持

2.湖南省教育廳優(yōu)秀青年基金項(xiàng)目：降生物胺魏斯氏菌的篩選及其關(guān)鍵基因的解析（23B0306），6萬(wàn)元，2023-2025年，主持

【主要科研論文】

1.Jianli Tang, Haocheng He, Yunlong Li, Zhudong Liu, Ziyuan Xia, Li Cao, Zirong Zhu, Ling Shuai, Yang Liu, Qianqian Wan, Yuewen Luo, Youming Zhang, Jie Rang* and Liqiu Xia*. Comparative proteomics reveals the effect of transcriptional regulator Sp13016 on butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Journal of Agricultural and Food Chemistry, 2021, 69(42): 12554-12565.

2.Jianli Tang, Jianming Chen, Yang Liu, Jinjuan Hu, Ziyuan Xia, Xiaomin Li, Haocheng He, Jie Rang, Yunjun Sun, Ziquan Yu, Jun Cui and Liqiu Xia*. The global regulator PhoU positively controls growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Frontiers in Microbiology, 2022, 13: 904627.

3.Jianli Tang, Zirong Zhu, Haocheng He, Zhudong Liu, Ziyuan Xia, Jianming Chen, Jinjuan Hu, Li Cao, Jie Rang*, Ling Shuai, Yang Liu, Yunjun Sun, Xuezhi Ding, Shengbiao Hu, Liqiu Xia*. Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Microbial Cell Factories, 2021, 20(1): 157.

4.Haocheng He, Jianli Tang, Jianming Chen, Jinjuan Hu, Zirong Zhu, Yang Liu, Ling Shuai, Li Cao, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu, Youming Zhang, Jie Rang*, Liqiu Xia*. Flaviolin-like gene cluster deletion optimized the butenyl-spinosyn biosynthesis route in Saccharopolyspora pogona [J]. ACS synthetic biology, 2021, 10(10):2740-2752.

5.Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun and Liqiu Xia*. Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a [J]. Microbial Cell Factories, 2018, 17(1): 31.

6.Zhudong Liu, Zirong Zhu, Jianli Tang, Haocheng He, Qianqian Wan, Yuewen Luo, Weitao Huang, Ziquan Yu, Yibo Hu, Xuezhi Ding and Liqiu Xia*. RNA-seq-based transcriptomic analysis of Saccharopolyspora spinosa revealed the critical function of PEP phosphonomutase in replenishment pathway [J]. Journal of Agricultural and Food Chemistry, 2020, 68(49):14660-14669.

7.Zhudong Liu, Jie Xiao, Jianli Tang, Yang Liu, Ling Shuai, Li Cao, Ziyuan Xia, Xuezhi Ding, Jie Rang*, Liqiu Xia*. Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa [J]. Microbial Cell Factories, 2021, 20(1): 141.

8.Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu* and Liqiu Xia*. Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy [J]. Journal of Biological Engineering, 2019, 13: 58.