科研情況: ? 近5年科研項(xiàng)目: 1、國家自然科學(xué)基金青年基金項(xiàng)目,21804012,“胞漿蛋白輔助熒光放大”高靈敏檢測及熒光成像成纖維細(xì)胞活化蛋白,2019/01-2021/12,已結(jié)題,主持。 2、湖南省自然科學(xué)基金青年基金項(xiàng)目,2019JJ50634,金屬離子輔助熒光放大納米探針構(gòu)建及其在炎癥性腸病成像中的應(yīng)用,2019/01-2021/12,已結(jié)題,主持。 3、湖南省教育廳優(yōu)秀青年基金項(xiàng)目,23B0308,ATP輔助信號(hào)放大熒光成像抑郁癥相關(guān)單胺氧化酶A,2023/10-2025/10,在研,主持。 4、長沙市自然科學(xué)基金,kq2208216,ATP多價(jià)結(jié)合驅(qū)動(dòng)信號(hào)放大策略的構(gòu)建及肝硬化成像分析,2023/01-2024/12,在研,主持。 5、區(qū)域遺傳性出生缺陷防控研究湖南省重點(diǎn)實(shí)驗(yàn)室開放基金重點(diǎn)項(xiàng)目,HPKL2023009,類酶催化熒光放大體系的構(gòu)建及胚胎Zn2+成像應(yīng)用研究,2023/10-2025/10,在研,主持。 6、化學(xué)生物傳感與計(jì)量學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放基金項(xiàng)目,2021018,基于H-聚集的零背景熒光信號(hào)放大納米探針的構(gòu)建及胚胎多硫化氫成像研究,2022/04-2024/04,在研,主持。 ? 近5年科研論文: (1)Yibo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang,* Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing,* Ronghua Yang.* A Polymeric Nanobeacon for Revealing Hydrogen Polysulfides Fluctuation during Fertilization and Embryonic Development. Angew. Chem. Int. Ed., 2022, 61, e202114504. (A1, IF=16.6, VIP論文) (2)Ni Zeng, Xiuhong Guan, Xiaowen Liu, Huiqiu Shi, Nan Li, Ruimeng Yang, Yibo Zhou*. Fibroblast activation protein-sensitive polymeric nanobeacon for early diagnosis of renal fibrosis. Biosensors and Bioelectronics, 2024, 253, 116144. (A1, IF=12.6) (3)Huihong Liu, Xianqing Zeng, Honghui Yin, Jing Chen, Wenzhi Xie, Guoqiang Zhou, Guojiang Mao, Yibo Zhou*, Sheng Yang*. A pH-switchable azo-based fluorescence reporter for lysosome-confined visualization of hypoxia status. Sensors & Actuators: B. Chemical., 2023, 381, 133431. (A1, IF=8.4) (4)Yibo Zhou*, Shan Hu, Hongwen Liu, Xinyue Xiao, Weiju Chen, Sheng Yang, Huiqiu Shi, Zhenxuan Gu, Junbin Li, Ronghua Yang* and Zhihe Qing*. Activity-Independent Enzyme-Powered Amplification for Improving Signal Stability and Fidelity in Biosensing. Chemical & Biomedical Imaging, 2024, 2, 4, 304-312 (A1, 封面論文) (5)Yibo Zhou*, Jun Zhang, Shuanghong Sun, Weiju Chen, Yuping Wang, Huiqiu Shi, Ronghua Yang,* and Zhihe Qing*. Amplified biosensor powered by endogenous molecules for intracellular fluorescence imaging. Analytical Chemistry, 2024, 96, 20, 8078-8090. (A1, IF=7.4) (6)Junbin Li, Na Wang, Mengyi Xiong*, Min Dai, Cheng Xie, Qianqian Wang, Ke Quan, Yibo Zhou*, and Zhihe Qing*. A Reaction-Based Ratiometric Bioluminescent Platform for Point-of-Care and Quantitative Detection Using a Smartphone, Analytical Chemistry, 2023, 95, 18, 7142-7149. (A1, IF=7.4) (7)Yibo Zhou, Xiaofei Ma, Shan Hu, Sheng Yang, Jingru Guo, Junbin Li, Yue-Fei Zhang, Juewen Liu, Zhihe Qing*, and Ronghua Yang*. Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging, Analytical Chemistry, 2023, 95, 21, 8318-8324. (A1, IF=7.4) (8)Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li*, Yibo Zhou.* Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe, Analytica Chimica Acta, 2023, 1265, 341356. (A1, IF=6.2) (9)Yibo Zhou*, Hao Dong, Zhengxuan Gu, Sheng Yang, Minzhi Ouyang, Zhihe Qing, Xiaofei Ma, Shan Hu, JunBin Li, and Ronghua Yang*. Self-Immolative Dye-Doped Polymeric Probe for Precisely Imaging Hydroxyl Radicals by Avoiding Leakage. Analytical Chemistry, 2021, 93, 12944-12953. (A1, IF=7.4) (10)Yibo Zhou, Keyi Yin, Hao Dong, Sheng Yang*, JunBin Li, Jinqiu Luo, Yi Li, and Ronghua Yang*. Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe. Analytical Chemistry, 2021, 93, 3726-3732. (A1, IF=7.4) (11)Yibo Zhou, Sheng Yang*, Jingru Guo, Hao Dong, Keyi Yin, Wei Tao Huang, and Ronghua Yang*. In Vivo Imaging of Hypoxia Associated with Inflammatory Bowel Disease by a Cytoplasmic Protein-Powered Fluorescence Cascade Amplifier. Analytical Chemistry, 2020, 92, 5787-5794. (A1, IF=7.4) (12)Yibo Zhou, Sheng Yang*, Yue Xiao, Zhen Zou, Zhihe Qing, Juewen Liu, and Ronghua Yang*. Cytoplasmic Protein-Powered In Situ Fluorescence Amplification for Intracellular Assay of Low-Abundance Analyte. Analytical Chemistry, 2019, 91, 15179-15186. (A1, IF=7.4) ?科研獎(jiǎng)勵(lì): 1. 湖南省自然科學(xué)二等獎(jiǎng) 2. 長沙理工大學(xué)“湖湘學(xué)者”青年英才 3. 湖南省化學(xué)化工學(xué)會(huì)第十八屆青年化學(xué)化工獎(jiǎng) 4. 湖南省優(yōu)秀碩士論文指導(dǎo)教師 ? 近5年申請(qǐng)專利: 1. 周怡波,尹柯儀,楊榮華。一種能長時(shí)間成像FAP的生物發(fā)光探針及其應(yīng)用, 2022-9-13, 中國, ZL2020 1 0860240.4 2. 周怡波,胡山,楊榮華。一種響應(yīng)ATP的熒光染料及其制備方法和應(yīng)用, 2024-1-3, 中國, ZL 2022 1 1374678.7 3. 周怡波,胡山,肖新月,卿志和。一種響應(yīng)羧酸酯酶熒光染料及其制備方法及應(yīng)用,2023-12-15, 中國, 202311730996.7 |