科研情況: ? 主要研究方向: 1、多功能核酸納米球合成; 2、納米發(fā)光材料的綠色合成; 3、生物傳感器在生物檢測及醫(yī)學(xué)應(yīng)用。 ? 近5年科研項(xiàng)目: 1、國家自然科學(xué)基金應(yīng)急項(xiàng)目(21645009),多功能DNA核酶熒光膠束對細(xì)胞內(nèi)信使RNA成像及基因治療研究, 執(zhí)行時(shí)間:2017.01-2017.12;結(jié)題, 主持。 2、湖南省自然科學(xué)基金面上項(xiàng)目(2018JJ2419),多功能核酶-納米囊泡對乳腺腫瘤細(xì)胞成像及基因治療研究,執(zhí)行時(shí)間:2018.1-2020.12;結(jié)題, 主持。 ? 近5年科研論文: 1. Jing-Lin He*, Yang Zhang, Ting-Ting Mei, Ling Tang, Si-Ying Huang, Zhong Cao*. Telomerase-triggered DNAzyme spiders for exponential amplified assay of cancer cells. Biosensors and Bioelectronics, 2019, 144, 111692. 2. Jing-Lin He*, Yang Zhang, Chan Yang, Si-Ying Huang, Ling Wu, Ting-Ting Mei, Jianxiu Wang, Zhong Cao*. Hybridization chain reaction based DNAzyme fluorescent sensor for L-histidine assay. Analytical Methods, 2019, 11, 2204. 3. Jing-Lin He*, Xing-Xing Wang, Ting-Ting Mei, Ling Wu, Ju-Lan Zeng, Jian-Hui Wang, Jianxiu Wang, Donghong Yu and Zhong Cao*, DNA-templated copper nanoclusters obtained?via?TdT isothermal nucleic acid amplification for mercury(II) assay. Anal. Methods, 2019, 11, 4165 4. Jing-Lin He*, Ting-Ting Mei, Ling Tang, Shi-Qing Liao, Zhong Cao*, DSN/TdT recycling digestion based cyclic amplification strategy for microRNA assay. Talanta 219 (2020) 121173 ? 專利與成果轉(zhuǎn)化: 1、何婧琳;微電極生物傳感器及其在檢測端粒酶中的應(yīng)用,2020-04-28,中國,ZL201810040231.3. 2、何婧琳;基于DNA-銀納米簇檢測癌細(xì)胞的靶向熒光探針及應(yīng)用,2021-02-19,中國,ZL201810332674.X. |