科研情況： ? 主要研究方向： 1、生物傳感和環(huán)境監(jiān)測與表面分析 ? 近5年科研項(xiàng)目： 1、湖南省人民醫(yī)院委托項(xiàng)目，肝膽癌生物標(biāo)志物自動化快速檢測平臺的技術(shù)開發(fā)，執(zhí)行時(shí)間：2021.07-2023.06；在研，主持。 2、湖南省教育廳一般項(xiàng)目（21C0195），Cr(VI)誘變性與致毒性的電化學(xué)表面等離子體激元共振研究，執(zhí)行時(shí)間：2022.01-2023.12；在研，主持。 3、國家自然科學(xué)面上項(xiàng)目（21876208），DNA損傷所介導(dǎo)的信號分子的表面等離子體激元共振檢測，執(zhí)行時(shí)間：2019.01-2023.12；在研，參與。 ? 近5年科研論文： 1.Ling Wu, Hailin Tang, Shengqiang Hu, Yonghong Xia, Zhixuan Lu, Yujuan Fan, ZixiaoWang, Xinyao Yi,* Feimeng Zhou* and Jianxiu Wang*, Sensitive and Simultaneous Surface Plasmon Resonance Detection of Free and p53-Bound MDM2 Proteins from Human Sarcomas, Analyst, 2018, 143, 2029. 2.Yonghong Xia?, Ling Wu?, Yuqing Hu, Yuhan He, Zhong Cao, Xu Zhu, Xinyao Yi*, Jianxiu Wang*. Sensitive Surface Plasmon Resonance Detection of Methyltransferase Activity and Screening of its Inhibitors Amplified by p53 Protein Bound to Methylation-Specific ds-DNA Consensus Sites, Biosensors and Bioelectronics, 2019, 126, 269-274. 3.Ling Wu, Yuqing Hu, Yuhan He, Yonghong Xia, Hanwen Lu, Zhong Cao, Xinyao Yia, Jianxiu Wang. Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3, Analyst, 2019, 144, 3959–3966. 4.Ling Wu, Yuhan He, Yuqing Hu, Hanwen Lu, Zhong Cao, Xinyao Yia, Jianxiu Wang. Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein, Analyst, 2019, 144, 6033-6040. 5.Yuhan He, Zixiao Wang, Yuqing Hu, Xinyao Yi, Ling Wu*, Zhong Cao, Jianxiu Wang*. Sensitive, Selective Monitoring of DNA Damage-Induced Intracellular p21 Protein and Unraveling the Role of p21 Protein in DNA Repair and Cell Apoptosis by Surface Plasmon Resonance, Analyst, 2020, 145, 3697-3704. 6.Kai-Jie Zhu1, Li Zhou1, Ling Wu*, Sai-Fei Feng, Hui-Ying Hu, Jing-Lin He, Yu-Min He, Ze-Meng Feng, Yu-Long Yin, Donghong Yu, Zhong Cao*. An Enzyme-Free Amperometric Sensor Based on Self-Assembling Ferrocene-Conjugated Oligopeptide for Specific Determination of Larginine. Chin. J. Chem. 2021, 39, 2755-2762. |
